In recent decades, bio-medical materials are widely used in implants and repair surgeries due to their high strength, wear, corrosion resistance, and biocompatibility ( Saini, 2015). Additionally, the prospects for the development and use of these alloys in implant applications are put forward. In this paper, the progression and application of titanium-based HEAs, as well as their preparation and biological evaluation methods, are comprehensively reviewed. The properties of these HEA materials can be predicted and regulated. The advent of the high-entropy alloy (HEA) as an innovative and advanced idea emerged to develop the medical implant materials through the specific HEA designs. Since the traditional metal implant materials are not highly compatible with the human body, the modern materials with excellent mechanical properties and proper biocompatibility should be developed urgently in order to solve any adverse reactions caused by the long-term implantations. With the continuous progress and development in the biomedicine field, metallic biomedical materials have attracted the considerable attention of researchers, but the related procedures need to be further developed. 5Chengsteel Group Co., Ltd., HBIS Group Co., Ltd., Chengde, China.4State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, Shanghai, China.3Institute for Materials Research, Tohoku University, Sendai, Japan.2Hubei Key Laboratory of Advanced Technology for Automotive Components, Wuhan University of Technology, Wuhan, China.1School of Metallurgical Engineering, Xi’an University of Architecture and Technology, Xi’an, China.Ning Ma 1 Shifeng Liu 1* Wei Liu 1 Lechun Xie 2* Daixiu Wei 3* Liqiang Wang 4 Lanjie Li 5 Beibei Zhao 5 Yan Wang 1*
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